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In this podcast, Dr. Upton Allen, Professor of Pediatrics and Chief of Pediatric Infectious Diseases at the Hospital for Sick Children at the University of Toronto, discusses the Second Edition of the AST Guidelines for Infections after Transplantation. Dr. Allen emphasizes some of the new data in this edition of the guidelines compared to the first edition. This podcast provides practical information on how to access and best make use of the guidelines to assist in caring for transplant recipients with infectious complications as well as preventing infections in this patient population.